HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride | HCID 45156751 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine | HCID 22562145 | 43.9% |
Reaction Steps
A solution of 1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine dihydrochloride (D40, 0.70 g) in water (5 ml) was basified to pH 12 with solid K2CO3, then extracted with dichloromethane and the combined organic extract was dried (MgSO4) and concentrated under vacuum to dryness, to afford 1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine as a pale yellow solid (0.22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288412B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-59c9024759484771ae22f7bfbcd26252 |
| Source note | uspto-grants-2012_10 |