Potassium Carbonate → 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine

HRID 2064185Notes

Reaction equation

HRID 2064185 reaction equation
Cl.Cl.[O:3]1[CH2:8][CH2:7][CH:6]([N:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)[CH2:5][CH2:4]1.C([O-])([O-])=O.[K+].[K+]>O>[O:3]1[CH2:4][CH2:5][CH:6]([N:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 451567511-(Oxan-4-yl)piperidin-4-amine dihydrochloride

Product 1

HCID 225621451-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amineYield 43.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine dihydrochloride (D40, 0.70 g) in water (5 ml) was basified to pH 12 with solid K2CO3, then extracted with dichloromethane and the combined organic extract was dried (MgSO4) and concentrated under vacuum to dryness, to afford 1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine as a pale yellow solid (0.22 g).

Workup

  1. extractionextracted with dichloromethane
  2. extractionthe combined organic extract
  3. dry with materialwas dried (MgSO4)
  4. concentrationconcentrated under vacuum to dryness

Sources & evidence

ORD record
ord-59c9024759484771ae22f7bfbcd26252
Source dataset
uspto-grants-2012_10
Patent number
US08288412B2

Reaction notes

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