反应详情

A solution of 1,1-dimethylethyl 4-{5-chloro-6-[(1-methylethyl)oxy]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-piperidinecarboxylate (D86, 140 mg, 0.34 mmol) in dichloromethane (3 ml) was treated with trifluoroacetic acid (3 ml) and stirred at room temperature under argon for 1 hr. The mixture was concentrated under vacuum and the residue treated with 10% Na2CO3 solution and extracted with ethyl acetate (×3). The combined extract was dried (MgSO4) and concentrated under vacuum to leave the title compound as a red oil (94 mg, 83%). M++H=310.0.

1. concentrationThe mixture was concentrated under vacuum
2. additionthe residue treated with 10% Na2CO3 solution
3. extractionextracted with ethyl acetate (×3)
4. extractionThe combined extract
5. dry with materialwas dried (MgSO4)
6. concentrationconcentrated under vacuum