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HRID2064373

反应详情

EQUATION

反应方程式

HRID 2064373 的结构方程式

REACTANTS

反应物

3
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CS(=O)(=O)Cl
HCID31297

Methanesulfonyl chloride

CH3ClO2S

结构：CN1CC2=C(C1=O)[C@@H](c1ccc(C#N)cc1S(C)(=O)=O)NC(=O)N2c1cccc(C(F)(F)F)c1
HCID58133678

未命名化合物

PRODUCTS

生成物

1
结构：CN1CC2=C(C1=O)[C@@H](c1ccc(C#N)cc1S(C)(=O)=O)N(S(C)(=O)=O)C(=O)N2c1cccc(C(F)(F)F)c1
HCID58133774

4-[(4S)-2,3,4,5,6,7-Hexahydro-6-methyl-3-(methylsulfonyl)-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-1H-pyrrolo[3,4-d]pyrimidin-4-yl]-3-(methylsulfonyl)benzonitrile

C23H19F3N4O6S2

PROCEDURE

实验过程

Analogously to the preparation of Example 27, 4-{(4S)-6-methyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-d]pyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile (20 mg, 41 μmol; Example 35), sodium hydride (60%, 2.3 mg, 57 μmol) and methanesulfonyl chloride (6.5 mg, 57 μmol) were reacted with one another for 2 h. The title compound was obtained as a colorless solid (1.7 mg, 7% of theory). In addition, 6.4 mg (32% of theory) of the starting material were recovered.

WORKUP

后处理

  1. customwere reacted with one another for 2 h