1-Methylpiperazine → HCID 178480878, compound

HRID 2064609Notes

Reaction equation

CN1CCNCC1.[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[CH:38]=[CH:37][C:24]3[NH:25][C:26]([C:28]4[N:29]=[N:30][C:31]5[C:36]=4[CH2:35][CH:34]=[CH:33][CH:32]=5)=[N:27][C:23]=3[CH:22]=2)=[O:20])[CH2:11][CH2:10]1>>[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[CH:38]=[CH:37][C:24]3[NH:25][C:26]([C:28]4[C:36]5[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=5)[NH:30][N:29]=4)=[N:27][C:23]=3[CH:22]=2)=[O:20])[CH2:11][CH2:10]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 178480877HCID 178480877, compound

Product 1

HCID 178480878HCID 178480878, compound

Procedure

By proceeding in a manner similar to Example 246(ab) above but using 443-(aminopropyl))-1-methyl piperazine there was prepared 2-(4H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid [3-(4-methyl-piperazin-1-yl)-propyl]-amide as an oil. MS: 416.21 (M+H)+. HPLC (Method L): RT=4.46 minutes.

Sources & evidence

ORD record: ord-62f8ab22f1394f3d90ae378272f43655
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288425B2

Reaction notes

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