Diethylcarbamoyl chloride → HCID 178464228, compound

HRID 2064626Notes

Reaction equation

[F:1][C:2]([F:22])([F:21])[C:3]1[CH:20]=[CH:19][C:6]2[NH:7][C:8]([C:10]3[C:14]4[CH2:15][NH:16][CH2:17][CH2:18][C:13]=4[NH:12][N:11]=3)=[N:9][C:5]=2[CH:4]=1.[CH2:23]([N:25]([CH2:29][CH3:30])[C:26](Cl)=[O:27])[CH3:24]>>[CH2:23]([N:25]([CH2:29][CH3:30])[C:26]([N:16]1[CH2:17][CH2:18][C:13]2[NH:12][N:11]=[C:10]([C:8]3[NH:7][C:6]4[CH:19]=[CH:20][C:3]([C:2]([F:1])([F:21])[F:22])=[CH:4][C:5]=4[N:9]=3)[C:14]=2[CH2:15]1)=[O:27])[CH3:24]

Participants

Reactant 2

HCID 6916Diethylcarbamoyl chloride

HCID 178506088HCID 178506088, compound

Product 1

HCID 178464228HCID 178464228, compound

Procedure

By proceeding in a manner similar to Example 258(a) above but using 3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine [Example 251(d)] and diethylcarbamyl chloride there was prepared 3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-1,4,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid diethylamide (103 mg) as a white solid. MS: 407.17 (M+H)+. HPLC (METHOD E1): RT=10.81 minutes.

Sources & evidence

ORD record: ord-c424fa397d764311936e58427bd92928
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288425B2

Reaction notes

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