Sodium Chloride → HCID 178499521, compound

HRID 2064638Notes

Reaction equation

HRID 2064638 reaction equation
[CH3:1][O:2][CH:3]([O:8][CH3:9])[C:4](=O)[CH:5]=[CH2:6].O.[NH2:11][NH2:12].[Cl-].[Na+]>O>[CH3:1][O:2][CH:3]([O:8][CH3:9])[C:4]1[CH:5]=[CH:6][NH:12][N:11]=1

Participants

5

Reactant 3

HCID 5234Sodium ChlorideHCID 24654Hydrazine hydrate (1:1)HCID 224778181,1-Dimethoxybut-3-en-2-one

Product 1

HCID 178499521HCID 178499521, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred solution of 1,1-dimethoxy-but-3-en-2-one in water (300 μL) was treated dropwise with hydrazine hydrate (21 mL). After standing at room temperature overnight the reaction mixture was treated with sodium chloride (108 g) and the mixture was then extracted with methyl-t-butylether (200 mL then 100 mL). The combined extracts were dried with magnesium sulfate and then evaporated to give 1H-pyrazol-3-carbaldehyde dimethyl acetal as a light brown oil (18.47 g).

Workup

  1. extractionthe mixture was then extracted with methyl-t-butylether (200 mL
  2. dry with materialThe combined extracts were dried with magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-caba686c7eda47d4a095333e2e89df10
Source dataset
uspto-grants-2012_10
Patent number
US08288425B2

Reaction notes

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