Semicarbazide hydrochloride → Ethyl pyruvate semicarbazide

HRID 2064687Notes

Reaction equation

HRID 2064687 reaction equation
Cl.[NH2:2][NH:3][C:4]([NH2:6])=[O:5].C([O-])(=O)C.[Na+].[C:12]([O:17][CH2:18][CH3:19])(=[O:16])[C:13]([CH3:15])=[O:14]>O>[NH2:2][NH:3][C:4]([NH2:6])=[O:5].[C:12]([O:17][CH2:18][CH3:19])(=[O:16])[C:13]([CH3:15])=[O:14]

Participants

5

Reactant 3

HCID 11236Semicarbazide hydrochlorideHCID 12041Ethyl pyruvateHCID 517045Sodium Acetate

Product 1

HCID 22477923Ethyl pyruvate semicarbazide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred solution of semicarbazide hydrochloride (11.1 g) and sodium acetate (8.2 g) in water (250 ml) was treated with ethyl pyruvate (10.9 ml) in one portion. The resulting white precipitate was collected by filtration to yield ethyl pyruvate semicarbazide (16.59 g) as a white powder. LC-MS (Method J): RT=2.38 minutes, 174.31 (M+H)+, 172.32 (M−H)−.

Workup

  1. filtrationThe resulting white precipitate was collected by filtration

Sources & evidence

ORD record
ord-42d7fae5a75e4dcb82798d3b57f29007
Source dataset
uspto-grants-2012_10
Patent number
US08288425B2

Reaction notes

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