6-Methylimidazo[2,1-B][1,3]thiazole-5-carboxylic acid → (1S,3S,5S)-3-{[(6-methyl-imidazo[2,1-b]thiazole-5-carbonyl)-amino]-methyl}-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester

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Reaction Steps

prepared by reaction of (1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester with 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid. LC-MS (acidic): tR=0.84 min; [M+H]+=377.1. 1H-NMR (CDCl3): δ=0.54 (bs, 1H); 0.80-0.86 (m, 1H); 1.50 (s, 9H); 1.51-1.58 (m, 1H); 1.77 (bd, J=11.8 Hz, 1H); 2.53-2.61 (m, 1H); 2.68 (s, 3H); 3.17-3.24 (m, 1H); 3.59-3.69 (m, 2H); 4.39-4.45 (m, 1H); 6.84 (d, J=4.3 Hz, 1H); 7.79 (bs, 1H); 8.27 (d, J=4.4, 1H).

Provenance & Evidence