Hydrochloric Acid → HCID 67081463, compound

HRID 2064812Notes

Reaction equation

HRID 2064812 reaction equation
Cl.C(OC([N:9]1[C@H:14]([CH2:15][NH:16][C:17]2[N:22]=[CH:21][C:20]([Br:23])=[CH:19][N:18]=2)[CH2:13][C@H:12]2[C@@H:10]1[CH2:11]2)=O)(C)(C)C>O1CCOCC1>[C@H:10]12[CH2:11][C@H:12]1[CH2:13][C@@H:14]([CH2:15][NH:16][C:17]1[N:22]=[CH:21][C:20]([Br:23])=[CH:19][N:18]=1)[NH:9]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67081544HCID 67081544, compound

Product 1

HCID 67081463HCID 67081463, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of HCl in dioxane (4.0 M, 30 mL) is added to a solution of (1S,3S,5S)-3-[(5-bromo-pyrimidin-2-ylamino)-methyl]-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester (5.40 mmol) in dioxane (30 mL). After 2 h the solvents are removed in vacuo to give a crude product which is used without further purification. LC-MS: tR=0.63 min; [M+H]+=269.0.

Workup

  1. customAfter 2 h the solvents are removed in vacuo

Sources & evidence

ORD record
ord-4c18470a55284b1393050b8387288799
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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