2-(3-chlorophenyl)benzoic Acid → 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid [(1S,3S,5S)-2-(3'-chloro-biphenyl-2-carbonyl)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide

HRID 2064840Notes

Reaction equation

HRID 2064840 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][C@@H:3]([CH2:7][NH:8][C:9]([C:11]1[C:20]3[O:19][CH2:18][CH2:17][O:16][C:15]=3[CH:14]=[CH:13][CH:12]=1)=[O:10])[NH:2]2.[Cl:21][C:22]1[CH:23]=[C:24]([C:28]2[C:29]([C:34](O)=[O:35])=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:25]=[CH:26][CH:27]=1>>[Cl:21][C:22]1[CH:23]=[C:24]([C:28]2[C:29]([C:34]([N:2]3[C@H:3]([CH2:7][NH:8][C:9]([C:11]4[C:20]5[O:19][CH2:18][CH2:17][O:16][C:15]=5[CH:14]=[CH:13][CH:12]=4)=[O:10])[CH2:4][C@H:5]4[C@@H:1]3[CH2:6]4)=[O:35])=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 27574152-(3-chlorophenyl)benzoic AcidHCID 670814142,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid [(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide

Product 1

HCID 670813252,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid [(1S,3S,5S)-2-(3'-chloro-biphenyl-2-carbonyl)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide

Procedure

prepared by reaction of 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid [(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide with 3′-chloro-biphenyl-2-carboxylic acid. LC-MS (basic): tR=1.43 min; [M+H]+=489.0.

Sources & evidence

ORD record
ord-4345ae7d13a24467853b4c119c77a578
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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