HCID 67081142, compound → HCID 67081168, compound

HRID 2064902Notes

Reaction equation

HRID 2064902 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:29]2[CH:30]=[C:31]([CH3:35])[CH:32]=[CH:33][CH:34]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:17]([C:19]3[CH:20]=[CH:21][CH:22]=[C:23]4[S:27][C:26](Cl)=[N:25][C:24]=34)=[O:18])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1>CO.[Pd]>[CH3:1][C:2]1[S:3][C:4]([C:29]2[CH:30]=[C:31]([CH3:35])[CH:32]=[CH:33][CH:34]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:17]([C:19]3[CH:20]=[CH:21][CH:22]=[C:23]4[S:27][CH:26]=[N:25][C:24]=34)=[O:18])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

Participants

4

Reactant 1

HCID 67081142HCID 67081142, compound

Product 1

HCID 67081168HCID 67081168, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-Chloro-benzothiazole-4-carboxylic acid [(1S,3S,5S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide (4.2 mg) is added to a suspension of Pd/C (10%, 10.0 mg) in MeOH (1.0 mL). The mixture is stirred at RT under a hydrogen atmosphere (1 bar) for 3 h. After filtration through celite and washing with MeOH the solvents are removed in vacuo to give the desired product. LC-MS (acidic): tR=1.01 min; [M+H]+=489.1.

Workup

  1. filtrationAfter filtration through celite
  2. washwashing with MeOH the solvents
  3. customare removed in vacuo

Sources & evidence

ORD record
ord-9e00aa9a14f24ef097cd7ec3128d59b1
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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