Nitrogen → HCID 66928589, compound

HRID 2064959Notes

Reaction equation

HRID 2064959 reaction equation
N#N.[N+:3]([C:6]1[CH:7]=[N:8][N:9]([CH2:11][C:12]2[O:16][N:15]=[C:14]([CH:17]([OH:19])[CH3:18])[CH:13]=2)[CH:10]=1)([O-:5])=[O:4]>C(Cl)Cl.O=[Mn]=O>[N+:3]([C:6]1[CH:7]=[N:8][N:9]([CH2:11][C:12]2[O:16][N:15]=[C:14]([C:17](=[O:19])[CH3:18])[CH:13]=2)[CH:10]=1)([O-:5])=[O:4]

Participants

5

Reactant 2

HCID 947NitrogenHCID 669288751-[5-(4-Nitro-pyrazol-1-ylmethyl)-isoxazol-3-yl]-ethanol

Product 1

HCID 66928589HCID 66928589, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-[5-(4-nitro-pyrazol-1-ylmethyl)-isoxazol-3-yl]-ethanol (435 mg, 1.83 mmol) in CH2Cl2 (8.0 mL) was treated at rt with MnO2 (1.32 g, 13.70 mmol) and the reaction mixture was stirred for 16 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound. LC-MS-conditions 02: tR=0.87 min.

Workup

  1. filtrationbefore being filtered through Celite
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-ab2ab2eae83b4ad9b05176c2b6751fc5
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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