Nitrogen → [4-(2-Methyl-[1,3]dioxolan-2-yl)-pyridin-2-yl]-methanol

HRID 2064987노트

반응식

HRID 2064987 반응식
N#N.[CH3:3][C:4]1([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH:15]=[O:16])[CH:10]=2)[O:8][CH2:7][CH2:6][O:5]1.[BH4-].[Na+].O>CO>[CH3:3][C:4]1([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH2:15][OH:16])[CH:10]=2)[O:5][CH2:6][CH2:7][O:8]1

참가 물질

6

반응물 4

HCID 947NitrogenHCID 962WaterHCID 4311764Sodium borohydrideHCID 866494804-(2-Methyl-[1,3]dioxolan-2-yl)-pyridine-2-carbaldehyde

생성물 1

HCID 66929049[4-(2-Methyl-[1,3]dioxolan-2-yl)-pyridin-2-yl]-methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), 4-(2-methyl-[1,3]dioxolan-2-yl)-pyridine-2-carbaldehyde (195 mg, 1.01 mmol) was dissolved in MeOH (5 mL). NaBH4 (49 mg, 1.25 mmol) was added portionwise at 0° C. and the reaction mixture was stirred at rt for 1 h. Water was added and the mixture extracted with EA (3×10 mL). The combined org. extracts were dried over Na2SO4, filtered, and the solvents were removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.41 min; [M+H]+=196.51.

후처리

  1. extractionthe mixture extracted with EA (3×10 mL)
  2. dry with materialextracts were dried over Na2SO4
  3. filtrationfiltered
  4. customthe solvents were removed under reduced pressure

출처 및 근거

ORD 기록
ord-a642af70bcb245608787f318c17ac571
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288419B2

반응 노트

불러오는 중…