反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-ethanol (193 mg, 0.75 mmol) in AcCN (5.0 mL) was treated at rt with MnO2 (362 mg, 3.75 mmol). The reaction mixture was stirred for 16 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a white solid. TLC: rf (1:1 hept-EA)=0.69. LC-MS-conditions 02: tR=1.04 min, [M+H]+=255.84.

1. filtrationbefore being filtered through Celite
2. customThe solvent was removed under reduced pressure