3-(Trifluoromethoxy)cinnamic Acid → (E)-N-[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide

HRID 2065168Notes

Reaction equation

HRID 2065168 reaction equation
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)[O:6]CCO1.[F:17][C:18]([F:32])([F:31])[O:19][C:20]1[CH:21]=[C:22](/[CH:26]=[CH:27]/[C:28](O)=[O:29])[CH:23]=[CH:24][CH:25]=1>>[O:6]=[C:2]([CH3:1])[CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([NH:16][C:28](=[O:29])/[CH:27]=[CH:26]/[C:22]2[CH:23]=[CH:24][CH:25]=[C:20]([O:19][C:18]([F:31])([F:32])[F:17])[CH:21]=2)[CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 7358403-(Trifluoromethoxy)cinnamic AcidHCID 669287261-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine

Product 1

HCID 66929327(E)-N-[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide

Procedure

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine and (E)-3-(3-trifluoromethoxy-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-d86a342de7604aad88b33f9fdcd1a69e
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

Loading…