2-Chlorocinnamic acid → (E)-3-(2-Chloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-acrylamide

HRID 2065171Notes

Reaction equation

HRID 2065171 reaction equation
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)[O:6]CCO1.[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1/[CH:24]=[CH:25]/[C:26](O)=[O:27]>>[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1/[CH:24]=[CH:25]/[C:26]([NH:16][C:14]1[CH:13]=[N:12][N:11]([CH2:10][CH2:9][CH2:8][CH2:7][C:2](=[O:6])[CH3:1])[CH:15]=1)=[O:27]

Participants

3

Reactant 2

HCID 7006422-Chlorocinnamic acidHCID 669287261-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine

Product 1

HCID 66928253(E)-3-(2-Chloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-acrylamide

Procedure

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine and (E)-3-(2-chloro-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-f9d3d740202c4aa1be13ea9054a00574
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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