2-Chlorocinnamic acid → (E)-3-(2-Chloro-phenyl)-N-[1-(5,5-difluoro-hexyl)-1H-pyrazol-3-yl]-acrylamide

HRID 2065212Notes

Reaction equation

HRID 2065212 reaction equation
[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]1.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1/[CH:22]=[CH:23]/[C:24](O)=[O:25]>>[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1/[CH:22]=[CH:23]/[C:24]([NH:12][C:9]1[CH:10]=[CH:11][N:7]([CH2:6][CH2:5][CH2:4][CH2:3][C:2]([F:1])([F:14])[CH3:13])[N:8]=1)=[O:25]

Participants

3

Reactant 2

HCID 7006422-Chlorocinnamic acidHCID 669283041-(5,5-Difluoro-hexyl)-1H-pyrazol-3-ylamine

Product 1

HCID 66929356(E)-3-(2-Chloro-phenyl)-N-[1-(5,5-difluoro-hexyl)-1H-pyrazol-3-yl]-acrylamide

Procedure

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-3-ylamine and (E)-3-(2-chloro-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.13 min; [M+H]+=368.25.

Sources & evidence

ORD record
ord-700e6b41963747388c150d5f92c29b5d
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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