2',3'-Dimethoxycinnamic acid → (E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-(2,3-dimethoxy-phenyl)-acrylamide

HRID 2065242Notes

Reaction equation

HRID 2065242 reaction equation
[F:1][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].[CH3:17][O:18][C:19]1[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=1/[CH:27]=[CH:28]/[C:29](O)=[O:30]>>[F:4][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH:16][C:29](=[O:30])/[CH:28]=[CH:27]/[C:20]3[CH:21]=[CH:22][CH:23]=[C:24]([O:25][CH3:26])[C:19]=3[O:18][CH3:17])=[N:12]2)=[CH:7][CH:6]=1)([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 7358422',3'-Dimethoxycinnamic acidHCID 669293691-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 66929290(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-(2,3-dimethoxy-phenyl)-acrylamide

Procedure

Following general procedure B, starting from 1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(2,3-dimethoxy-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.09 min; [M+H]+=418.09.

Sources & evidence

ORD record
ord-60bbc2883e49426aa7dff7d72c68aff3
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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