2-Propenoic acid, 3-(3-chlorophenyl)- → (E)-3-(3-Chloro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide

HRID 2065248Notes

Reaction equation

HRID 2065248 reaction equation
[F:1][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].[Cl:17][C:18]1[CH:19]=[C:20](/[CH:24]=[CH:25]/[C:26](O)=[O:27])[CH:21]=[CH:22][CH:23]=1>>[Cl:17][C:18]1[CH:19]=[C:20](/[CH:24]=[CH:25]/[C:26]([NH:16][C:13]2[CH:14]=[CH:15][N:11]([CH2:10][C:8]3[O:9][C:5]([C:2]([F:1])([F:4])[CH3:3])=[CH:6][CH:7]=3)[N:12]=2)=[O:27])[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 7352502-Propenoic acid, 3-(3-chlorophenyl)-HCID 669293691-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 66928427(E)-3-(3-Chloro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide

Procedure

Following general procedure B, starting from 1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(3-chloro-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.14 min; [M+H]+=392.14.

Sources & evidence

ORD record
ord-51b29225ec9140b58e4e4a4fea3da88d
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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