5-(4-Chlorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → 5-(4-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide

HRID 2065326Notes

Reaction equation

HRID 2065326 reaction equation
[CH3:1][C:2]1([C:7]2[S:11][C:10]([CH2:12][N:13]3[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[S:30][C:29]([CH3:31])=[N:28][C:27]=2[C:32](O)=[O:33])=[CH:22][CH:21]=1>>[C:2]([C:7]1[S:11][C:10]([CH2:12][N:13]2[CH:17]=[C:16]([NH:18][C:32]([C:27]3[N:28]=[C:29]([CH3:31])[S:30][C:26]=3[C:23]3[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=3)=[O:33])[CH:15]=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 231463175-(4-Chlorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 66928512HCID 66928512, compound

Product 1

HCID 669283925-(4-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide

Procedure

Following general procedure X followed by C, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-ylmethyl]-1H-pyrazol-4-ylamine and 5-(4-chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid. LC-MS-conditions 05c: tR=0.77 min; [M+H]+=457.15.

Sources & evidence

ORD record
ord-0ab72f42763645d4a529b50802ead108
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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