反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of {1-[2-(1-hydroxy-ethyl)-thiazol-4-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-chloro-benzyl ester in AcCN (1.0 mL) was treated at rt with MnO2 (49.2 mg, 0.51 mmol) and the reaction mixture was stirred at rt overnight before being filtered through Celite to give the title compound as a brown foam. LC-MS-conditions 02: tR=0.98 min; [M+H]+=390.98.

1. filtrationbefore being filtered through Celite