1-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine → 5-(6-Trifluoromethyl-pyridin-2-yl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide

HRID 2065347Notes

Reaction equation

HRID 2065347 reaction equation
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[Li+].[F:20][C:21]([F:37])([F:36])[C:22]1[N:27]=[C:26]([C:28]2[O:32][CH:31]=[N:30][C:29]=2[C:33]([O-])=[O:34])[CH:25]=[CH:24][CH:23]=1>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[CH:17]=[C:16]([NH:18][C:33]([C:29]3[N:30]=[CH:31][O:32][C:28]=3[C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([C:21]([F:37])([F:20])[F:36])[N:27]=3)=[O:34])[CH:15]=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 669286111-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamineHCID 66928955HCID 66928955, compound

Product 1

HCID 669283435-(6-Trifluoromethyl-pyridin-2-yl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide

Procedure

Following general procedure Z3 followed by C, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine and 5-(6-trifluoromethyl-pyridin-2-yl)-oxazole-4-carboxylic acid lithium salt. LC-MS-conditions 02: tR=0.92 min; [M+H]+=446.24.

Sources & evidence

ORD record
ord-291e4d48ea414ee08561169b045c21a2
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

Loading…