反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 5-phenyl-oxazole-4-carboxylic acid {1-[2-(1-hydroxy-ethyl)-oxazol-5-ylmethyl]-1H-pyrazol-3-yl}-amide (140 mg, 0.37 mmol) in AcCN (4.0 mL) was treated at rt with MnO2 (267 mg, 2.77 mmol) and the reaction mixture was stirred at rt overnight before being filtered through Celite. Purification of the residue by FC (3:7 hept-EA) gave the title compound as a white foam. TLC: rf (3:7 hept-EA)=0.28. LC-MS-conditions 02: tR=0.95 min; [M+H]+=378.21.

1. filtrationbefore being filtered through Celite
2. customPurification of the residue by FC (3:7 hept-EA)