反应详情

温度

55 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of {1-[2-(1-hydroxy-ethyl)-oxazol-4-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-chloro-benzyl ester (211 mg, 0.56 mmol) in AcCN (5.0 mL) was treated at rt with MnO2 (270 mg, 2.80 mmol) and the reaction mixture was stirred at 55° C. for 3 h before being filtered through Celite. Purification of the residue by FC (2:1 to 1:2 hept-EA) gave the title compound as a pale yellow oil. TLC: rf (EA)=0.60. LC-MS-conditions 02: tR=0.94 min; [M+H]+=375.16.

1. filtrationbefore being filtered through Celite
2. customPurification of the residue by FC (2:1 to 1:2 hept-EA)