HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (E)-1-(3-chloro-2-fluorophenyl)-N-(trimethylsilylmethyl)methanimine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(Trimethylsilyl)methylamine | HCID 87488 | — |
| Reactant | 3-Chloro-2-fluorobenzaldehyde | HCID 736335 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-1-(3-chloro-2-fluorophenyl)-N-(trimethylsilylmethyl)methanimine | HCID 58398999 | 99% |
Reaction Steps
To a solution of (aminomethyl)trimethylsilane (Fluka) (1.03 g, 10 mmol) in dichloromethane (50 mL) was added 3-chloro-2-fluoro-benzaldehyde (Oakwood) (1.6 g, 10 mmol). The reaction mixture was stirred at room temperature for 3 h. Water was added. The organic layer was separated, washed with brine, dried over MgSO4, and concentrated to give [1-(3-chloro-2-fluoro-phenyl)-meth-(E)-ylidene]-trimethylsilanylmethyl-amine as a colorless oil (2.4 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288431B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3dc9d582b5f542b882b2262f94f5aee6 |
| Source note | uspto-grants-2012_10 |