Hydrochloric Acid → HCID 178478745, compound

HRID 2065460Notes

Reaction equation

HRID 2065460 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)(C)(C)C.C(Cl)[Cl:23].[ClH:25]>O1CCOCC1>[ClH:23].[ClH:25].[N:18]1[CH:19]=[CH:20][C:15]([O:14][C@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 178454068HCID 178454068, compound

Product 1

HCID 178478745HCID 178478745, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of tert-butyl[trans-4-(pyridin-4-yloxy)cyclohexyl]carbamate in a solution of methylene chloride (1 mL) and 4.0 M of hydrogen chloride in 1,4-dioxane (2 mL) was stirred at r.t for 2 hours. The mixture was concentrated to yield 45% of trans-4-(pyridin-4-yloxy)cyclohexanamine dihydrochloride (2-step).

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-0d086e0176844ed58145b1a66cd632b7
Source dataset
uspto-grants-2012_10
Patent number
US08288417B2

Reaction notes

Loading…