Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Morpholinopiperidine | HCID 795724 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22061300 | HCID 22061300 | — |
Reaction Steps
10.00 kg (58.74 mol) 4-(4-piperidinyl)-morpholine (N) were placed in 100.0 L ethanol and heated to 50° C. At 50° C., 12.15 kg (123.35 mol) conc. hydrochloric acid (37%) were metered in. The resulting suspension was cooled to 20° C. and stirred for 30 minutes at 20° C. The product was centrifuged off and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288531B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-63641b5bfdfb434490042b83d89481f7 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
