Hydrochloric Acid → HCID 22061300, compound

HRID 2065480Notes

Reaction equation

HRID 2065480 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:13]>C(O)C>[ClH:13].[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 7957244-Morpholinopiperidine

Product 1

HCID 22061300HCID 22061300, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

10.00 kg (58.74 mol) 4-(4-piperidinyl)-morpholine (N) were placed in 100.0 L ethanol and heated to 50° C. At 50° C., 12.15 kg (123.35 mol) conc. hydrochloric acid (37%) were metered in. The resulting suspension was cooled to 20° C. and stirred for 30 minutes at 20° C. The product was centrifuged off and dried.

Workup

  1. customAt 50° C.
  2. temperatureThe resulting suspension was cooled to 20° C.
  3. customdried

Sources & evidence

ORD record
ord-63641b5bfdfb434490042b83d89481f7
Source dataset
uspto-grants-2012_10
Patent number
US08288531B2

Reaction notes

Loading…