Chloroform → HCID 67359781, compound

HRID 2065606Notes

Reaction equation

HRID 2065606 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH3:16][O:17][C:18]1[CH:32]=[C:31]2[C:21]([NH:22][CH:23]=[C:24]2[CH2:25][CH:26]([C:28]([OH:30])=[O:29])[NH2:27])=[CH:20][CH:19]=1.C(Cl)(Cl)Cl>CO>[C:12]([OH:14])(=[O:13])[CH3:11].[C:28]([CH:26]([NH:27][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:25][C:24]1[C:31]2[C:21](=[CH:20][CH:19]=[C:18]([O:17][CH3:16])[CH:32]=2)[NH:22][CH:23]=1)([OH:30])=[O:29]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 1198025-MethoxytryptophanHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 67359781HCID 67359781, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 5-methoxy-DL-tryptophan to provide the title compound in 85% yield as yellow needles (flash chromatography on SiO2, eluent CHCl3, MeOH, AcOH—10, 1, 0.2).

Sources & evidence

ORD record
ord-a25123394aea4ddfa979239448353350
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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