1-Amino-2,3-dihydro-1H-indene-1-carboxylic acid → HCID 45254375, compound

HRID 2065612Notes

Reaction equation

HRID 2065612 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][C:17]1([C:26]([OH:28])=[O:27])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19][CH2:18]1>>[C:26]([C:17]1([NH:16][C:2]2[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=3)[N:3]=2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19][CH2:18]1)([OH:28])=[O:27]

Participants

3

Reactant 2

HCID 2338101-Amino-2,3-dihydro-1H-indene-1-carboxylic acidHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45254375HCID 45254375, compoundYield 8%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-1-aminoindan-1-carboxylic acid to provide the title compound in 8% yield as yellow needles (flash chromatography on SiO2, eluent CHCl3, MeOH, AcOH—15, 1, 0.2 and recrystallization from MeOH).

Sources & evidence

ORD record
ord-5c1712e5b0c946a99ac30961eb8672e9
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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