Dl-Tryptophan → 2-[1-Carboxy-2-(1H-indol-3-yl)-ethylamino]-6,8-dichloro-quinoline-3-carboxylic acid
Reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([Cl:16])[CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:17][CH:18]([C:29]([OH:31])=[O:30])[CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1>>[C:29]([CH:18]([NH:17][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([Cl:16])[CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)([OH:31])=[O:30]Participants
3
Procedure
In close analogy to the procedure described in Example 1, 2,6,8-trichloroquinoline-3-carboxylic acid is reacted with DL-tryptophan to provide the title compound in good yield.
Sources & evidence
- ORD record
- ord-8512a1faf0614ecd8285f3a218db846a
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288549B2
Reaction notes
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