DL-Glutamine → HCID 67358746, compound

HRID 2065654Notes

Reaction equation

HRID 2065654 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][CH2:22][C:23](=[O:25])[NH2:24])[C:18]([OH:20])=[O:19]>>[C:23]([CH2:22][CH2:21][CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[C:18]([OH:20])=[O:19])(=[O:25])[NH2:24]

Participants

3

Reactant 2

HCID 738DL-GlutamineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 67358746HCID 67358746, compound

Procedure

In close analogy to the procedure described in Example 32, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-4-carbamoyl-butyric acid to provide the title compound in moderate yield. LCMS m/z 352 (M+1).

Sources & evidence

ORD record
ord-e374a59168fb4c53ab45ac0b79dbc044
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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