2-Amino-3-phenyl-succinic acid → 2-(3-Carboxy-6-chloro-quinolin-2-ylamino)-3-phenyl-succinic acid

HRID 2065656Notes

Reaction equation

HRID 2065656 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH:21]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:22]([OH:24])=[O:23])[C:18]([OH:20])=[O:19]>>[C:12]([C:11]1[C:2]([NH:16][CH:17]([CH:21]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]([OH:24])=[O:23])[C:18]([OH:20])=[O:19])=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([Cl:15])=[CH:6][CH:5]=2)([OH:14])=[O:13]

Participants

3

Reactant 2

HCID 3108842-Amino-3-phenyl-succinic acidHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 452557792-(3-Carboxy-6-chloro-quinolin-2-ylamino)-3-phenyl-succinic acid

Procedure

In close analogy to the procedure described in Example 32, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-phenyl-succinic acid [J. Med. Chem. 1973, 16, 1277-1280] to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-06cae4cf880f4da49698b09184403f89
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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