HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-phenyl-succinic acid → 2-(3-Carboxy-6-chloro-quinolin-2-ylamino)-3-phenyl-succinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-phenyl-succinic acid | HCID 310884 | — |
| Reactant | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| Product | 2-(3-Carboxy-6-chloro-quinolin-2-ylamino)-3-phenyl-succinic acid | HCID 45255779 | — |
Reaction Steps
In close analogy to the procedure described in Example 32, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-phenyl-succinic acid [J. Med. Chem. 1973, 16, 1277-1280] to provide the title compound in moderate yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-06cae4cf880f4da49698b09184403f89 |
| Source note | uspto-grants-2012_10 |