Dl-Phenylalanine → HCID 67358158, compound

HRID 2065663Notes

Reaction equation

C([O:3][C:4]([C:6]1[C:7](Cl)=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][C:12]([Cl:16])=[CH:11][C:10]=2[CH3:17])=[O:5])C.[NH2:19][CH:20]([C:28]([OH:30])=[O:29])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:28]([CH:20]([NH:19][C:7]1[C:6]([C:4]([OH:3])=[O:5])=[CH:15][C:14]2[C:9](=[C:10]([CH3:17])[CH:11]=[C:12]([Cl:16])[CH:13]=2)[N:8]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([OH:30])=[O:29]

Participants

Reactant 2

HCID 994Dl-Phenylalanine

HCID 86656382HCID 86656382, compound

Product 1

HCID 67358158HCID 67358158, compound

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloro-8-methyl-quinoline-3-carboxylic acid ethyl ester is reacted with DL-phenylalanine to provide the title compound in moderate yield as yellow powder.

Sources & evidence

ORD record: ord-5fb0ce557c6e486cabeeb5f0a40f7ccc
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288549B2

Reaction notes

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