2-Chloronicotinic acid → HCID 45256527, compound

HRID 2065669Notes

Reaction equation

HRID 2065669 reaction equation
[C:1]([CH:4]([NH:13][C:14]1[C:23]([C:24]([OH:26])=[O:25])=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[C:19]([Cl:27])[CH:20]=2)[N:15]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)([OH:3])=[O:2].Cl[C:29]1[N:37]=[CH:36][CH:35]=[CH:34][C:30]=1[C:31]([OH:33])=[O:32]>>[C:1]([C@@H:4]([NH:13][C:14]1[C:23]([C:24]([OH:26])=[O:25])=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[C:19]([Cl:27])[CH:20]=2)[N:15]=1)[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][C:29]2[C:30]([C:31]([OH:33])=[O:32])=[CH:34][CH:35]=[CH:36][N:37]=2)=[CH:10][CH:11]=1)([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 762582-Chloronicotinic acidHCID 67357599HCID 67357599, compound

Product 1

HCID 45256527HCID 45256527, compound

Procedure

In close analogy to the procedure described in Example 96, 2-[1-carboxy-2-(4-hydroxy-phenyl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid is reacted with 2-chloronicotinic acid to provide the title compound in a form of diammonia salt after chromatography on silica (aq. ammonia containing eluent).

Sources & evidence

ORD record
ord-20035e22d20d4ab4a054b81341eaff71
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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