HRID2065672

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID847163

2-chloroquinoline-3-carboxylic acid

C10H6ClNO2

结构：O=C(O)c1cc2cc(Br)ccc2nc1NC(Cc1ccc(O)cc1)C(=O)O

HCID45256529

未命名化合物

PRODUCTS

生成物

结构：O=C(O)c1cc2cc(Br)ccc2nc1NC(Cc1ccc(Oc2nc3ccccc3cc2C(=O)O)cc1)C(=O)O

HCID45256530

未命名化合物

PROCEDURE

实验过程

In close analogy to the procedure described in Example 96, 6-bromo-2-[1-carboxy-2-(4-hydroxy-phenyl)-ethylamino]-quinoline-3-carboxylic acid is reacted with 2-chloro-quinoline-3-carboxylic acid to provide the title compound in good yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-30a5ea7e1b7541999c0b410db3c7ae70
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08288549B2
来源说明: uspto-grants-2012_10

反应 SMILES

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH:13]([C:22]([OH:24])=[O:23])[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[C:6]([C:25]([OH:27])=[O:26])=[CH:5]2.Cl[C:29]1[C:38]([C:39]([OH:41])=[O:40])=[CH:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[N:30]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH:13]([C:22]([OH:24])=[O:23])[CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][C:29]3[C:38]([C:39]([OH:41])=[O:40])=[CH:37][C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[N:30]=3)=[CH:19][CH:20]=1)[C:6]([C:25]([OH:27])=[O:26])=[CH:5]2