HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroquinoline-3-carboxylic acid → 6-Bromo-2-{1-carboxy-2-[4-(3-carboxy-quinolin-2-yloxy)-phenyl]-ethylamino}-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroquinoline-3-carboxylic acid | HCID 847163 | — |
| Reactant | 6-Bromo-2-[1-carboxy-2-(4-hydroxy-phenyl)-ethylamino]-quinoline-3-carboxylic acid | HCID 45256529 | — |
| Product | 6-Bromo-2-{1-carboxy-2-[4-(3-carboxy-quinolin-2-yloxy)-phenyl]-ethylamino}-quinoline-3-carboxylic acid | HCID 45256530 | — |
Reaction Steps
In close analogy to the procedure described in Example 96, 6-bromo-2-[1-carboxy-2-(4-hydroxy-phenyl)-ethylamino]-quinoline-3-carboxylic acid is reacted with 2-chloro-quinoline-3-carboxylic acid to provide the title compound in good yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-30a5ea7e1b7541999c0b410db3c7ae70 |
| Source note | uspto-grants-2012_10 |