L-Phenylalanine → HCID 67358194, compound

HRID 2065690Notes

Reaction equation

HRID 2065690 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([CH3:16])[CH:6]=[C:7]([CH3:15])[CH:8]=2)[N:3]=1.[NH2:17][C@H:18]([C:26]([OH:28])=[O:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>CS(C)=O>[C:26]([C@@H:18]([NH:17][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([CH3:16])[CH:6]=[C:7]([CH3:15])[CH:8]=2)[N:3]=1)[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([OH:28])=[O:27]

Participants

4

Reactant 2

HCID 6140L-PhenylalanineHCID 11331612-Chloro-6,8-dimethylquinoline-3-carboxylic acid

Product 1

HCID 67358194HCID 67358194, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2-chloro-6,8-dimethyl-quinoline-3-carboxylic acid is reacted with L-phenylalanine in DMSO to provide the title compound in good yield. LCMS m/z 364 (M+).

Sources & evidence

ORD record
ord-59f9327887964453a030a3c509e85118
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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