HCID 23284249, compound → HCID 67359160, compound

HRID 2065691Notes

Reaction equation

HRID 2065691 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]([NH:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[C:18]([OH:20])=[O:19]>CN(C=O)C>[CH2:25]([NH:24][C:22]([CH2:21][CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[C:18]([OH:20])=[O:19])=[O:23])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 23284249HCID 23284249, compoundHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 67359160HCID 67359160, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-N-benzyl-succinamic acid [J. Pharm. Sci. 1980, 69 (5), 553-555.] in DMF to provide the title compound in good yield.

Sources & evidence

ORD record
ord-a62fa0b87a8d4d2cab3c398ec4f895ce
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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