Hydrochloric Acid → HCID 44474092, compound

HRID 2065750Notes

Reaction equation

HRID 2065750 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[CH3:21])[CH:10]([C:22]([N:24]2[CH2:29][CH2:28][N:27]([C:30]3[CH:35]=[C:34]([CH3:36])[CH:33]=[CH:32][C:31]=3[CH3:37])[CH2:26][CH2:25]2)=[O:23])[CH2:9]1)=O)(C)(C)C.[ClH:38]>C(O)C>[ClH:38].[CH3:37][C:31]1[CH:32]=[CH:33][C:34]([CH3:36])=[CH:35][C:30]=1[N:27]1[CH2:28][CH2:29][N:24]([C:22]([CH:10]2[CH2:9][NH:8][CH2:13][CH2:12][N:11]2[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[CH3:21])=[O:23])[CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 687288443-[4-(2,5-Dimethyl-phenyl)-piperazine-1-carbonyl]-4-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 44474092HCID 44474092, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 3-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-4-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (133 mg) in ethanol (5 mL) was added a saturated solution of hydrogen chloride in ethanol (1 mL). The mixture was stirred at room temperature for 2 h, and was concentrated to give [4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-[1-(4-fluoro-2-methyl-phenyl)-piperazin-2-yl]-methanone hydrochloride as crude white solid, MS: 411.5 ([M+H]+).

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-983d48cd012249fdb8bc79e0661d8a51
Source dataset
uspto-grants-2012_10
Patent number
US08288541B2

Reaction notes

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