1,4-Dibenzylpiperazine-2-carboxylic acid → 1-(2,5-Xylyl)piperazine

HRID 2065759Notes

Reaction equation

HRID 2065759 reaction equation
C(N1CCN(CC2C=CC=CC=2)CC1C(O)=O)C1C=CC=CC=1.C(N1CCN(CC2C=CC=CC=2)CC1C([N:46]1[CH2:51][CH2:50][N:49]([C:52]2[CH:57]=[C:56]([CH3:58])[CH:55]=[CH:54][C:53]=2[CH3:59])[CH2:48][CH2:47]1)=O)C1C=CC=CC=1>>[CH3:59][C:53]1[CH:54]=[CH:55][C:56]([CH3:58])=[CH:57][C:52]=1[N:49]1[CH2:48][CH2:47][NH:46][CH2:51][CH2:50]1

Participants

3

Reactant 2

HCID 223242451,4-Dibenzylpiperazine-2-carboxylic acidHCID 68729979(1,4-Dibenzyl-piperazin-2-yl)-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-methanone

Product 1

HCID 705421-(2,5-Xylyl)piperazine

Procedure

In analogy to example 1, step 1, from 1,4-dibenzylpiperazine-2-carboxylic acid (CAS Reg. No.: [215597-67-4]) and 1-(2,5-dimethylphenyl)piperazine was prepared (1,4-dibenzyl-piperazin-2-yl)-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-methanone as a white foam, MS: 483.3 ([M+H]+).

Sources & evidence

ORD record
ord-958fa825890845b0bd959159d9a7b3a1
Source dataset
uspto-grants-2012_10
Patent number
US08288541B2

Reaction notes

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