Hydrochloric Acid → HCID 68728970, compound

Participants

Reaction Steps

To a solution of 4-(4-chloro-benzenesulfonyl)-2-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester (1.64 g) in ethanol (16.4 mL) was added a saturated solution of HCl in ethanol (16.4 mL) at 0° C. The reaction mixture was stirred at ambient temperature for 2 h and concentrated to give [4-(4-chloro-benzenesulfonyl)-piperazin-2-yl]-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-methanone hydrochloride, MS: 477.0 ([M+H, 1Cl]+).

Provenance & Evidence