Hydrochloric Acid → HCID 68728970, compound

HRID 2065763Notes

Reaction equation

HRID 2065763 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH:9]1[C:24]([N:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:37]=[C:36]([CH3:38])[CH:35]=[CH:34][C:33]=2[CH3:39])[CH2:28][CH2:27]1)=[O:25])=O)(C)(C)C.Cl>C(O)C>[ClH:23].[Cl:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH:9]([C:24]([N:26]3[CH2:27][CH2:28][N:29]([C:32]4[CH:37]=[C:36]([CH3:38])[CH:35]=[CH:34][C:33]=4[CH3:39])[CH2:30][CH2:31]3)=[O:25])[CH2:10]2)(=[O:15])=[O:16])=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68961791HCID 68961791, compound

Product 1

HCID 68728970HCID 68728970, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 4-(4-chloro-benzenesulfonyl)-2-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester (1.64 g) in ethanol (16.4 mL) was added a saturated solution of HCl in ethanol (16.4 mL) at 0° C. The reaction mixture was stirred at ambient temperature for 2 h and concentrated to give [4-(4-chloro-benzenesulfonyl)-piperazin-2-yl]-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-methanone hydrochloride, MS: 477.0 ([M+H, 1Cl]+).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-15850645e7b84949a0e83b9443b18058
Source dataset
uspto-grants-2012_10
Patent number
US08288541B2

Reaction notes

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