Nicotinic Acid → 121343-77-9

HRID 2065887Notes

Reaction equation

HRID 2065887 reaction equation
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.C(O[C:13](=O)[C:14]1[CH:19]=CC(Cl)=N[CH:15]=1)C.C([Mg]Cl)C(C)C>>[CH2:13]([C:5]1[CH:6]=[CH:7][C:2]([C:1]([OH:9])=[O:8])=[CH:3][N:4]=1)[CH:14]([CH3:19])[CH3:15]

Participants

4

Reactant 3

HCID 938Nicotinic AcidHCID 2799611Ethyl 6-chloronicotinateHCID 178418368HCID 178418368, compound

Product 1

HCID 19865917121343-77-9

Procedure

6-Isobutyl-nicotinic acid is prepared in analogy to Nicotinic acid 2 from commercially available 6-chloronicotinic acid ethyl ester and isobutylmagnesium chloride; LC-MS: tR=0.52 min, [M+1]+=180.30.

Sources & evidence

ORD record
ord-29915a030c91465a86dfcd448c948a33
Source dataset
uspto-grants-2012_10
Patent number
US08288554B2

Reaction notes

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