Nicotinic Acid → HCID 59392506, compound

HRID 2065890Notes

Reaction equation

HRID 2065890 reaction equation
C([O:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][C:10](Cl)=[N:9][CH:8]=1)(C)(C)C.[CH3:15][CH:16]([CH3:21])[CH2:17][CH2:18][Mg]Br.C(O)(=O)C1C=CC=NC=1>>[CH3:15][CH:16]([CH3:21])[CH2:17][CH2:18][C:10]1[CH:11]=[CH:12][C:7]([C:6]([OH:5])=[O:14])=[CH:8][N:9]=1

Participants

4

Reactant 3

HCID 938Nicotinic AcidHCID 11521348Tert-butyl 6-chloropyridine-3-carboxylateHCID 178418529HCID 178418529, compound

Product 1

HCID 59392506HCID 59392506, compound

Procedure

6-(3-Methyl-butyl)-nicotinic acid is prepared by reacting 6-chloro-nicotinic acid tert-butly ester with 3-methyl-butylmagnesium bromide under Fürstner conditions as described for Nicotinic acid 2; LC-MS: tR=0.58 min, [M+1]+=194.30.

Sources & evidence

ORD record
ord-07f4f4bd9d8648e984c98830aca3c4e5
Source dataset
uspto-grants-2012_10
Patent number
US08288554B2

Reaction notes

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