3-Ethyl-4-hydroxy-5-methyl-benzoic acid → 2-Ethyl-4-[3-(6-isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol
Reaction equation
[OH:1][NH:2][C:3](=[NH:15])[C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([CH2:11][CH:12]([CH3:14])[CH3:13])=[N:6][CH:5]=1.[CH2:16]([C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([CH3:28])[C:26]=1[OH:27])[C:21](O)=O)[CH3:17]>>[CH2:16]([C:18]1[CH:19]=[C:20]([C:21]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][C:7]([CH2:11][CH:12]([CH3:13])[CH3:14])=[C:8]([CH3:10])[CH:9]=3)[N:15]=2)[CH:24]=[C:25]([CH3:28])[C:26]=1[OH:27])[CH3:17]Participants
3
Procedure
2-Ethyl-4-[3-(6-isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol is prepared from N-hydroxy-6-isobutyl-5-methyl-nicotinamidine and 3-ethyl-4-hydroxy-5-methyl-benzoic acid in analogy to Example 13, LC-MS: tR=1.02 min, [M+1]+=352.09.
Sources & evidence
- ORD record
- ord-4fecc7c8ec224d279c922b24ce9d6579
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288554B2
Reaction notes
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