HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethyl-4-hydroxy-5-methyl-benzoic acid → 2-Ethyl-4-[3-(6-isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethyl-4-hydroxy-5-methyl-benzoic acid | HCID 59234777 | — |
| Reactant | HCID 178426675 | HCID 178426675 | — |
| Product | 2-Ethyl-4-[3-(6-isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol | HCID 136170272 | — |
Reaction Steps
2-Ethyl-4-[3-(6-isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol is prepared from N-hydroxy-6-isobutyl-5-methyl-nicotinamidine and 3-ethyl-4-hydroxy-5-methyl-benzoic acid in analogy to Example 13, LC-MS: tR=1.02 min, [M+1]+=352.09.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288554B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4fecc7c8ec224d279c922b24ce9d6579 |
| Source note | uspto-grants-2012_10 |