反应详情

1-(2-{4-[5-(6-Isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid is prepared from {4-[5-(6-Isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetic acid and azetidine-3-carboxylic acid methyl ester in analogy to Example 55; stirring this material in 3 N aq. NaOH/dioxane at rt for 20 h gives the desired compound; LC-MS: tR=0.60, [M+1]+=434.96.